Griffonia simplicifolia (5-HTP) | Natura Foundation (2024)

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Griffonia simplicifolia (5-HTP) | Natura Foundation (2024)

FAQs

Is there a downside to taking 5-HTP? ›

Side effects of 5-HTP are generally mild and may include nausea, heartburn, gas, feelings of fullness, and rumbling sensations in some people. At high doses, serotonin syndrome, a dangerous condition caused by too much serotonin in the body, could develop.

What is Griffonia simplicifolia good for? ›

Griffonia simplicifolia is a shrub native to West Africa. Its seeds contain a chemical called 5-hydroxytryptophan (5-HTP) and are used as medicine. 5-HTP works in the brain and central nervous system by increasing the production of the chemical serotonin. Serotonin can affect sleep, appetite, pain, and mood.

What is the effect of Griffonia Simplicifolia? ›

Griffonia simplicifolia is an African shrub and a source of the compound 5-HTP. It has anxiety and appetite-reducing effects. Griffonia simplicifolia is most often used for Mental Health and Fat Loss.

Why did 5-HTP stop working? ›

Administration of 5-HTP alone depletes catecholamines (dopamine, norepinephrine, and epinephrine). When dopamine depletion is great enough, 5-HTP will no longer function.

What not to mix 5-HTP with? ›

Antidepressants -- People who are taking antidepressant medications should not take 5-HTP. These medications could combine with 5-HTP to cause serotonin syndrome, a dangerous condition characterized by mental changes, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma.

Is 5-HTP safer than antidepressants? ›

The 5-HTP was found to be as effective as the antidepressant, with fewer side effects. Never take 5-HTP if you are currently taking other medications, supplements, or substances without consulting your doctor first. Potentially dangerous drug interactions may occur.

Does 5-HTP make you feel happy? ›

Since 5-HTP increases serotonin levels, it is used for conditions in which serotonin is believed to play an important role. These include depression, anxiety, and many other conditions, but there is no good scientific evidence to support most of these uses.

Can you take 5-HTP everyday? ›

When taken by mouth: It is possibly safe to take 5-HTP in doses of up to 400 mg daily for up to one year. The most common side effects include heartburn, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems, and muscle problems. Large doses of 5-HTP, such as 6-10 grams daily, are possibly unsafe.

Is 5-HTP safe for heart? ›

Too much 5-HTP in your body can cause a spike in serotonin levels, resulting in side effects such as: anxiety. shivering. serious heart problems.

Why is 5-HTP banned? ›

Because antidepressants generally work by increasing serotonin in the brain, 5-HTP could combine with these medications to cause high concentrations of serotonin. Having too much serotonin can lead to serotonin syndrome, a serious condition characterized by dangerously high heart rate, blood pressure, and temperature.

Can 5-HTP cause weight gain? ›

Many other studies have also found that 5-HTP increased feelings of fullness and aided weight loss in people with overweight or obesity ( 9 , 10 ). Moreover, one older animal study found that 5-HTP could reduce excessive food intake due to stress ( 11 ).

Is L-theanine better than 5-HTP? ›

5-HTP has an average rating of 6.5 out of 10 from a total of 155 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 24% reported a negative effect. L-theanine has an average rating of 5.4 out of 10 from a total of 142 ratings on Drugs.com.

Does 5-HTP raise blood pressure? ›

5-HTP has been found to have a hypotensive effect on blood pressure. Studies on rats confirmed that it did have a blood pressure-lowering effect. More studies need to be carried out and it is not known yet whether the serotonin is a positive or negative influence on blood pressure.

Can you just stop taking 5-HTP? ›

Research suggests that 5-HTP is not addictive. However, if you use the substance for a long time and then stop, you may experience withdrawal symptoms such as dizziness, fatigue, and poor mood. These symptoms typically fade within a week. Also, although rare, some people become psychologically dependent on 5-HTP.

Does 5-HTP raise cortisol? ›

Absence of psychotic symptoms and commission of suicidal acts were associated with an increased cortisol response to 5-HTP in the depressed patients.

Can too much 5-HTP cause anxiety? ›

Too much 5-HTP in your body can cause a spike in serotonin levels, resulting in side effects such as: anxiety.

References

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