If you are someone who is concerned about memory loss and brain health, you may have come across Prevagen. Prevagen is a dietary supplement that claims to improve memory and cognitive function. It contains an ingredient called apoaequorin, which is a protein that comes from jellyfish.
While the idea of a supplement that can improve brain function may seem appealing, it is important to take a closer look at the evidence and claims behind Prevagen. The supplement has been the subject of controversy and legal action due to its health claims and lack of scientific evidence to back them up.
In this article, we will review Prevagen and examine the research behind it. We will also discuss potential side effects and whether the supplement is worth considering for those who are looking to improve their brain health and prevent memory loss.
What is Prevagen?
Prevagen is an over-the-counter dietary supplement marketed to older adults with claims to improve memory loss associated with aging and increase healthy brain function. It contains the active ingredient apoaequorin, a protein derived from jellyfish that binds to calcium ions.
Origins of Prevagen
The discovery of apoaequorin, the key ingredient in Prevagen, is credited to Osamu Shimomura, a Nobel Prize-winning biochemist who studied jellyfish. Apoaequorin is a calcium-binding protein that is found in the crystal jellyfish, Aequorea victoria, and is used to produce light.
Quincy Bioscience, the company that manufactures Prevagen, claims that apoaequorin can improve cognitive function by reducing neuronal damage caused by excess calcium in the brain.
How Does Prevagen Work?
According to the manufacturer, Prevagen works by binding to excess calcium in the brain, which can cause cellular damage and lead to memory loss. By reducing the amount of free calcium in the brain, Prevagen is believed to help protect neurons and improve cognitive function.
However, the scientific evidence supporting these claims is limited and controversial.
The FDA has issued warnings to Quincy Bioscience for making false and misleading claims about Prevagen’s effectiveness. A study conducted by the company found that Prevagen improved cognitive function in older adults, but a subsequent study by the FTC found no evidence to support these claims.
While the mechanism of action of apoaequorin is not fully understood, some studies have suggested that it may have antioxidant and anti-inflammatory effects. However, more research is needed to confirm these findings and to determine the safety and effectiveness of apoaequorin for improving cognitive function.
Prevagen and Brain Health
Prevagen is an over-the-counter product marketed to older adults with claims to improve memory loss associated with aging and increase healthy brain function, although clinical research is limited. But can Prevagen really help with brain health?
Cognitive Function and Memory
According to the Prevagen website, the active ingredient in the product, apoaequorin, “has been clinically shown to help with mild memory problems associated with aging.”
However, the evidence is mixed. Some studies have suggested that apoaequorin may improve cognitive function, while others have found no significant effect.
It’s important to note that while some people may experience improved memory and cognitive function while taking Prevagen, the product is not a cure for dementia or other serious memory disorders.
If you are experiencing significant memory loss or cognitive decline, it’s important to speak with your healthcare provider to determine the best course of treatment.
Prevagen and Dementia
While Prevagen is marketed as a memory supplement, it’s important to note that the product is not a treatment for dementia. Apparently, there is currently no cure for dementia, and while some medications may help with symptoms, they do not slow or stop the progression of the disease.
If you or a loved one is experiencing symptoms of dementia, such as memory loss, confusion, or difficulty with daily tasks, it’s important to speak with a healthcare provider as soon as possible. Early diagnosis and treatment can help manage symptoms and improve quality of life.
Prevagen as a Supplement
If you’re looking for a supplement that may help improve your memory and cognitive function, Prevagen is an option you might consider. This supplement claims to help prevent memory loss and improve concentration, and it comes in various forms to suit your needs.
In this section, we’ll take a closer look at Prevagen as a supplement, including its types, ingredient list, dosage, and usage.
Types of Prevagen Supplements
Prevagen is available in several forms, including capsules and chewable tablets. The supplement comes in three different strengths: regular strength, extra strength, and professional strength.
The regular strength contains 10 milligrams of apoaequorin per capsule, while the extra strength contains 20 milligrams of apoaequorin per capsule. The professional strength contains 40 milligrams of apoaequorin per capsule.
Ingredient List
The main ingredient in Prevagen is apoaequorin, a protein found in certain types of jellyfish. The supplement also contains vitamin D3, which is essential for maintaining strong bones, and calcium, which is important for overall health. The chewable tablets also contain a small amount of sugar and natural flavors to make them more palatable.
Dosage and Usage
The recommended dosage of Prevagen depends on the strength you choose. If you’re taking the regular strength, you should take one capsule per day. If you’re taking the extra strength, you should take one capsule per day. If you’re taking the professional strength, you should take one capsule every other day.
The supplement can be taken with or without food, and it’s important to follow the dosage instructions carefully to get the best results.
It’s also worth noting that Prevagen is not intended to treat, cure, or prevent any disease. If you’re experiencing memory loss or other cognitive issues, it’s important to talk to your doctor to determine the underlying cause and appropriate treatment options.
Research on Prevagen
Prevagen is a dietary supplement that has been marketed as a memory booster for older adults. The manufacturer claims that Prevagen can help with mild memory loss associated with aging. However, the health claims made by Prevagen have been subject to criticism, and the supplement has been the subject of federal investigations and legal actions.
Prevagen Clinical Studies
The manufacturer of Prevagen claims that the supplement is backed by clinical evidence. According to the company, clinical studies have shown that Prevagen improves cognitive function, including memory, learning, and recall. However, some studies conducted on Prevagen have been criticized for their design and methodology.
One study found that Prevagen was ineffective at improving cognitive function in older adults. The study was a randomized, double-blind, placebo-controlled trial involving 218 adults aged 40 to 91 years.
The participants were given either Prevagen or a placebo for 90 days, and their cognitive function was assessed at baseline and at the end of the study. The study found no significant difference in cognitive function between the Prevagen and placebo groups.
Criticism of Prevagen Studies
The health claims made by Prevagen have been subject to criticism by the Federal Trade Commission (FTC) and the state of New York. In 2017, the FTC and the state of New York sued the manufacturer of Prevagen for making false and unsubstantiated claims about the supplement’s effectiveness.
The lawsuit alleged that the manufacturer had misrepresented the results of clinical studies and had failed to disclose that the studies did not support the health claims made by the company.
With the lawsuit has already settled, with the manufacturer agreeing to pay $2 million in refunds to consumers who had purchased the supplement. The settlement also required the manufacturer to stop making false and unsubstantiated claims about the effectiveness of Prevagen.
In conclusion, while the manufacturer of Prevagen claims that the supplement is backed by clinical evidence, the studies conducted on Prevagen have been criticized for their design and methodology.
The health claims made by Prevagen have also been subject to criticism by the FTC and the state of New York. It is important to consult with a healthcare professional before taking any dietary supplement.
Customer Reviews of Prevagen
If you’re considering trying Prevagen, it’s important to know what other customers have experienced. Here, we’ll look at some of the positive and negative reviews of the product.
Positive Reviews
Many customers have reported positive experiences with Prevagen. Some have noted improved memory and clearer thinking, while others have experienced better focus and concentration.
One customer on Amazon wrote, “I’ve been taking Prevagen for a few months now and have noticed a significant improvement in my memory. I feel like I can remember things more easily and my mind feels clearer.”
Another customer said, “I’ve tried other memory supplements before, but Prevagen is the only one that has really worked for me. I feel more focused and alert, and I don’t have as much trouble remembering things.”
Overall, many customers have reported positive experiences with Prevagen, and it may be worth trying if you’re looking for a memory supplement.
Negative Reviews
While many customers have had positive experiences with Prevagen, others have reported negative side effects or no improvement in memory or cognitive function.
Some customers have reported headaches, dizziness, and nausea after taking Prevagen. Others have noted that they didn’t notice any improvement in their memory or cognitive function after taking the supplement.
One customer on Amazon wrote, “I’ve been taking Prevagen for a few weeks now, and I haven’t noticed any improvement in my memory. I’ve also had some headaches and dizziness since starting the supplement.”
Another customer said, “I tried Prevagen for a few months, but I didn’t notice any improvement in my memory or cognitive function. I also experienced some nausea and stomach discomfort while taking the supplement.”
While negative reviews of Prevagen are less common than positive reviews, it’s important to be aware of the potential side effects and the fact that not everyone may experience improved memory or cognitive function.
What Do Experts Say?
When it comes to Prevagen, opinions among experts are mixed. While some studies have shown potential benefits, others have raised concerns about the safety and effectiveness of the product.
According to the Harvard Health Blog, the Federal Trade Commission and New York state’s attorney general warned the makers of Prevagen in 2017 about making deceptive claims. The FDA has also issued warnings about the product’s marketing claims.
While the makers of Prevagen claim that the product can improve memory loss associated with aging and increase healthy brain function, clinical research has not conclusively supported these claims. Evidence about how well Prevagen works is limited, and there are concerns about whether our bodies can absorb and use its ingredients correctly.
Despite these concerns, some experts believe that apoaequorin, one of the active ingredients in Prevagen, may have potential benefits for brain health. According to WebMD, apoaequorin is a protein that comes from jellyfish and may help protect brain cells from damage.
However, more research is needed to fully understand the effects of apoaequorin on brain function and memory.
Who Is It Good For?
If you are an older adult looking to improve your memory and brain function, Prevagen may be a good option for you. It is marketed towards this demographic, as they tend to experience more memory loss and cognitive decline.
However, it is important to note that Prevagen is not meant for individuals who already have moderate memory loss or brain disease.
Prevagen is also suitable for individuals who are looking to maintain healthy brain function. It is not meant to treat or cure any disease, but rather to support cognitive health. If you are looking for a supplement to help improve your concentration and focus, Prevagen may be a good option for you.
It is important to consult with your healthcare provider before starting any new supplement regimen, especially if you are taking other medications or have any underlying health conditions. Your healthcare provider can help determine if Prevagen is a good fit for your individual needs and health status.
Who Should Avoid Prevagen?
While Prevagen is generally considered safe for most adults to take, there are certain groups of people who should avoid using it.
If you are pregnant or breastfeeding, it is recommended that you avoid taking Prevagen. There is not enough research to determine whether it is safe for pregnant or breastfeeding women to use.
If you have an allergy to milk or any of the other ingredients in Prevagen, you should not take this supplement. One of the main ingredients in Prevagen is apoaequorin, which is derived from jellyfish. Some people may have an allergic reaction to this ingredient.
If you are taking any medications, it is important to talk to your doctor before starting to take Prevagen. There is a risk of interactions between Prevagen and certain medications. For example, Prevagen may interact with medications that are used to treat Alzheimer’s disease, Parkinson’s disease, or depression.
If you have a medical condition, such as liver disease or kidney disease, it is important to talk to your doctor before taking Prevagen. There is not enough research to determine whether Prevagen is safe for people with these conditions.
Finally, if you are under the age of 18, you should not take Prevagen. This supplement is intended for adults only.
Cost and Where to Buy
If you’re interested in trying Prevagen, you may be wondering about the cost and where to buy it. Prevagen is available for purchase on the official website, as well as at major retailers such as CVS and Walgreens. You can also find it on Walmart’s website.
The cost of Prevagen varies depending on the strength and quantity of capsules. For example, a bottle of 30 regular strength capsules (each containing 10 milligrams of apoaequorin) costs around $40, while a bottle of 30 professional strength capsules (each containing 40 milligrams of apoaequorin) costs around $90.
It’s important to note that the prices may vary depending on the retailer and any promotions they may be running.
When purchasing Prevagen, be sure to check the expiration date and read the instructions carefully. It’s also important to keep in mind that Prevagen is not meant to treat, prevent, or cure any disease, and you should always consult with your healthcare provider before taking any new supplements.
Conclusion
After reviewing the available information on Prevagen and its potential effects on brain health, it is clear that this supplement is a popular choice among many individuals looking to improve their cognitive function. However, it is important to note that the scientific evidence supporting its efficacy is limited and controversial.
While some studies have shown positive results, others have found no significant improvement in memory or cognitive function. Additionally, the active ingredient in Prevagen, apoaequorin, has not been extensively studied and its mechanism of action is not well understood.
It is also worth noting that some users have reported side effects such as headaches, dizziness, and nausea. While these side effects are generally mild, they are still a concern for some individuals.
Overall, if you are considering taking Prevagen or any other brain health supplement, it is important to do your research and consult with a healthcare professional. While these supplements may offer some benefits, they are not a substitute for a healthy lifestyle and proper medical care.
Furthermore, it is important to be cautious of exaggerated or false claims made by supplement manufacturers. Always look for scientific evidence to support any claims about the effectiveness of a supplement.
In conclusion, while Prevagen may be a popular choice for some individuals looking to improve their cognitive function, it is important to approach it with caution and to make informed decisions based on the available evidence and consultation with a healthcare professional.
FAQ
What are the shipping options?
According to the official Prevagen website, the shipping options available depend on your location. Standard shipping is available for orders within the United States, and international shipping is available for orders outside of the United States.
Shipping rates and delivery times may vary depending on your location and the shipping method you choose.
What is the return policy?
The official Prevagen website states that if you’re not satisfied with your purchase, you can return the product within 30 days of the purchase date for a full refund. The product must be returned in its original packaging and in good condition.
Shipping and handling fees are not refundable, and you are responsible for the cost of return shipping.
Can Prevagen cure memory loss?
No, Prevagen is not meant to cure memory loss. The official Prevagen website states that the product is a dietary supplement that is intended to support brain health and improve cognitive function. It is not intended to diagnose, treat, cure, or prevent any disease.
What are the side effects of Prevagen?
According to a Prevagen review by Honest Brand Reviews, some users have reported side effects such as headache, dizziness, nausea, and constipation. However, the company has not listed any side effects on their website.
It’s important to talk to your doctor before taking any dietary supplement, especially if you have any medical conditions or are taking any medications.
Is Prevagen FDA approved?
No, Prevagen is not FDA approved. The official Prevagen website states that the product is a dietary supplement that is regulated by the FDA under the Dietary Supplement Health and Education Act (DSHEA) of 1994.
This means that the FDA does not review or approve dietary supplements before they are marketed, and the manufacturer is responsible for ensuring the safety and effectiveness of the product.
References
- “Apoaequorin.” PubMed, National Institute of Diabetes and Digestive and Kidney Diseases, 2012, www.ncbi.nlm.nih.gov/books/NBK552157/.
- Emmady, Prabhu D., et al. “Major Neurocognitive Disorder (Dementia).” PubMed, StatPearls Publishing, 2023, pubmed.ncbi.nlm.nih.gov/32491376/#:~:text=It%20is%20often%20a%20progressive. Accessed 27 Apr. 2023.
- “FTC, New York State Charge the Marketers of Prevagen with Making Deceptive Memory, Cognitive Improvement Claims.” Federal Trade Commission, 9 Jan. 2017, www.ftc.gov. Accessed 27 Apr. 2023.
- “FTC Sends Refunds to Consumers Who Bought Deceptively Marketed Supplements to Treat Pain and Age-Related Health Conditions.” Federal Trade Commission, 20 Oct. 2021, www.ftc.gov/news-events. Accessed 27 Apr. 2023.
- Grossman, Sara, et al. “Prevagen®: Analysis of Clinical Evidence and Its Designation as a “#1 Pharmacist Recommended Brand.”” The Senior Care Pharmacist, vol. 37, no. 8, 1 Aug. 2022, pp. 335–338, https://doi.org/10.4140/tcp.n.2022.335.
- Haines, Stuart T., and Sharon K. Park. “Vitamin D Supplementation: What’s Known, What to Do, and What’s Needed.” Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, vol. 32, no. 4, 27 Mar. 2012, pp. 354–382, https://doi.org/10.1002/phar.1037.
- Moran, Daniel L., et al. “Effects of a Supplement Containing Apoaequorin on Verbal Learning in Older Adults in the Community.” Advances in Mind-Body Medicine, vol. 30, no. 1, 2016, pp. 4–11, pubmed.ncbi.nlm.nih.gov/26878676/. Accessed 27 Apr. 2023.
- Snow, Alan D., et al. “In Vitro Comparison of Major Memory-Support Dietary Supplements for Their Effectiveness in Reduction/Inhibition of Beta-Amyloid Protein Fibrils and Tau Protein Tangles: Key Primary Targets for Memory Loss.” Scientific Reports, vol. 11, no. 1, 15 Feb. 2021, https://doi.org/10.1038/s41598-020-79275-1.
- “Strengthening the Regulation of Dietary Supplements—Lessons from Prevagen®.” Food and Drug Law Institute (FDLI), 16 Nov. 2021, www.fdli.org.
- Zimmer, Marc. “GFP: From Jellyfish to the Nobel Prize and Beyond.” Chemical Society Reviews, vol. 38, no. 10, 2009, p. 2823, https://doi.org/10.1039/b904023d.
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Dorothy Magos, (RND)
Dorothy, a Registered Nutritionist-Dietitian, is currently pursuing a master’s degree in Public Health (MPH), with a major in Public Health Nutrition. Her enthusiasm for imparting knowledge about food, nutrition, and health is evident through her love for teaching university students. Apart from this, she has a keen interest in coffee, traveling, writing, cycling, running, cooking, and baking.Education: Silliman University Master of Public Health (MPH), Public Health Nutrition (2018-2022), Silliman University Bachelor of Science (BS), Nutrition and Dietetics (2010-2014)
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